Author:
Hao Zhuowen,Chen Renxin,Chai Chen,Wang Yi,Chen Tianhong,Li Hanke,Hu Yingkun,Feng Qinyu,Li Jingfeng
Abstract
Bone tissue engineering has been becoming a promising strategy for surgical bone repair, but the risk of infection during trauma repair remains a problematic health concern worldwide, especially for fracture and infection-caused bone defects. Conventional antibiotics fail to effectively prevent or treat bone infections during bone defect repair because of drug-resistance and recurrence, so novel antibacterial agents with limited resistance are highly needed for bone tissue engineering. Antimicrobial peptides (AMPs) characterized by cationic, hydrophobic and amphipathic properties show great promise to be used as next-generation antibiotics which rarely induce resistance and show potent antibacterial efficacy. In this review, four common structures of AMPs (helix-based, sheet-based, coil-based and composite) and related modifications are presented to identify AMPs and design novel analogs. Then, potential effects of AMPs for bone infection during bone repair are explored, including bactericidal activity, anti-biofilm, immunomodulation and regenerative properties. Moreover, we present distinctive applications of AMPs for topical bone repair, which can be either used by delivery system (surface immobilization, nanoparticles and hydrogels) or used in gene therapy. Finally, future prospects and ongoing challenges are discussed.
Funder
National Natural Science Foundation of China
Science and Technology Program of Hubei Province
Natural Science Foundation of Hubei Province
Zhongnan Hospital of Wuhan University
Subject
Biomedical Engineering,Histology,Bioengineering,Biotechnology
Cited by
7 articles.
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