Author:
Céspedes-Valenzuela Daniela N.,Sánchez-Rentería Santiago,Cifuentes Javier,Gómez Saul C.,Serna Julian A.,Rueda-Gensini Laura,Ostos Carlos,Muñoz-Camargo Carolina,Cruz Juan C.
Abstract
Melanoma is an aggressive type of skin cancer that accounts for over 75% of skin cancer deaths despite comprising less than 5% of all skin cancers. Despite promising improvements in surgical approaches for melanoma resection, the survival of undetectable microtumor residues has remained a concern. As a result, hyperthermia- and drug-based therapies have grown as attractive techniques to target and treat cancer. In this work, we aim to develop a stimuli-responsive hydrogel based on chitosan methacrylate (ChiMA), porcine small intestine submucosa methacrylate (SISMA), and doxorubicin-functionalized reduced graphene oxide (rGO-DOX) that eliminates microtumor residues from surgically resected melanoma through the coupled effect of NIR light-induced photothermal therapy and heat-induced doxorubicin release. Furthermore, we developed an in silico model to optimize heat and mass transport and evaluate the proposed chemo/photothermal therapy in vitro over melanoma cell cultures.
Subject
Biomedical Engineering,Histology,Bioengineering,Biotechnology
Cited by
5 articles.
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