Author:
Zhang Jian,Liu Tiantian,Shi Zhongyan,Tan Shuping,Suo Dingjie,Dai Chunyang,Wang Li,Wu Jinglong,Funahashi Shintaro,Liu Miaomiao
Abstract
Patients with bipolar disorder have deficits in self-referenced information. The brain functional connectivity during social cognitive processing in bipolar disorder is unclear. Electroencephalogram (EEG) was recorded in 23 patients with bipolar disorder and 19 healthy comparison subjects. We analyzed the time-frequency distribution of EEG power for each electrode associated with self, other, and font reflection conditions and used the phase lag index to characterize the functional connectivity between electrode pairs for 4 frequency bands. Then, the network properties were assessed by graph theoretic analysis. The results showed that bipolar disorder induced a weaker response power and phase lag index values over the whole brain in both self and other reflection conditions. Moreover, the characteristic path length was increased in patients during self-reflection processing, whereas the global efficiency and the node degree were decreased. In addition, when discriminating patients from normal controls, we found that the classification accuracy was high. These results suggest that patients have impeded integration of attention, memory, and other resources of the whole brain, resulting in a deficit of efficiency and ability in self-referential processing.
Funder
National Key Research and Development Program of China
National Natural Science Foundation of China
Beijing Municipal Science and Technology Commission
China Postdoctoral Science Foundation
Subject
Cognitive Neuroscience,Aging
Cited by
5 articles.
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