Author:
Kuo Chih-Yun,Hsiao Hung-Ta,Lo Ing-Hsien,Nikolai Tomas
Abstract
Obstructive sleep apnea (OSA) and Alzheimer's disease (AD) are common in the elderly population. Obstructive sleep apnea that may cause significant changes in the cerebrospinal fluid β-amyloid and T-tau and/or P-tau protein levels is often identified as a risk factor for development of AD. Although the underlying mechanisms of AD are still not fully understood, a hypothesis associating OSA with AD has been already proposed. In this systematic mini-review, we first discuss the recent findings supporting the association of OSA with an increased risk of AD and then provide evidence suggesting the positive effect of OSA treatment on a reduced risk of AD.
Funder
Grantová Agentura, Univerzita Karlova
Subject
Cognitive Neuroscience,Ageing
Cited by
14 articles.
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