Author:
Boltze Johannes,Aronowski Jaroslaw A.,Badaut Jerome,Buckwalter Marion S.,Caleo Mateo,Chopp Michael,Dave Kunjan R.,Didwischus Nadine,Dijkhuizen Rick M.,Doeppner Thorsten R.,Dreier Jens P.,Fouad Karim,Gelderblom Mathias,Gertz Karen,Golubczyk Dominika,Gregson Barbara A.,Hamel Edith,Hanley Daniel F.,Härtig Wolfgang,Hummel Friedhelm C.,Ikhsan Maulana,Janowski Miroslaw,Jolkkonen Jukka,Karuppagounder Saravanan S.,Keep Richard F.,Koerte Inga K.,Kokaia Zaal,Li Peiying,Liu Fudong,Lizasoain Ignacio,Ludewig Peter,Metz Gerlinde A. S.,Montagne Axel,Obenaus Andre,Palumbo Alex,Pearl Monica,Perez-Pinzon Miguel,Planas Anna M.,Plesnila Nikolaus,Raval Ami P.,Rueger Maria A.,Sansing Lauren H.,Sohrabji Farida,Stagg Charlotte J.,Stetler R. Anne,Stowe Ann M.,Sun Dandan,Taguchi Akihiko,Tanter Mickael,Vay Sabine U.,Vemuganti Raghu,Vivien Denis,Walczak Piotr,Wang Jian,Xiong Ye,Zille Marietta
Abstract
The past decade has brought tremendous progress in diagnostic and therapeutic options for cerebrovascular diseases as exemplified by the advent of thrombectomy in ischemic stroke, benefitting a steeply increasing number of stroke patients and potentially paving the way for a renaissance of neuroprotectants. Progress in basic science has been equally impressive. Based on a deeper understanding of pathomechanisms underlying cerebrovascular diseases, new therapeutic targets have been identified and novel treatment strategies such as pre- and post-conditioning methods were developed. Moreover, translationally relevant aspects are increasingly recognized in basic science studies, which is believed to increase their predictive value and the relevance of obtained findings for clinical application.This review reports key results from some of the most remarkable and encouraging achievements in neurovascular research that have been reported at the 10th International Symposium on Neuroprotection and Neurorepair. Basic science topics discussed herein focus on aspects such as neuroinflammation, extracellular vesicles, and the role of sex and age on stroke recovery. Translational reports highlighted endovascular techniques and targeted delivery methods, neurorehabilitation, advanced functional testing approaches for experimental studies, pre-and post-conditioning approaches as well as novel imaging and treatment strategies. Beyond ischemic stroke, particular emphasis was given on activities in the fields of traumatic brain injury and cerebral hemorrhage in which promising preclinical and clinical results have been reported. Although the number of neutral outcomes in clinical trials is still remarkably high when targeting cerebrovascular diseases, we begin to evidence stepwise but continuous progress towards novel treatment options. Advances in preclinical and translational research as reported herein are believed to have formed a solid foundation for this progress.
Subject
Cognitive Neuroscience,Ageing