Altered Coupling Between Cerebral Blood Flow and Voxel-Mirrored Homotopic Connectivity Affects Stroke-Induced Speech Comprehension Deficits
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Published:2022-06-23
Issue:
Volume:14
Page:
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ISSN:1663-4365
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Container-title:Frontiers in Aging Neuroscience
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language:
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Short-container-title:Front. Aging Neurosci.
Author:
Zhang Jie,Shang Desheng,Ye Jing,Ling Yi,Zhong Shuchang,Zhang Shuangshuang,Zhang Wei,Zhang Li,Yu Yamei,He Fangping,Ye Xiangming,Luo Benyan
Abstract
The neurophysiological basis of the association between interhemispheric connectivity and speech comprehension processing remains unclear. This prospective study examined regional cerebral blood flow (CBF), homotopic functional connectivity, and neurovascular coupling, and their effects on comprehension performance in post-stroke aphasia. Multimodal imaging data (including data from functional magnetic resonance imaging and arterial spin labeling imaging) of 19 patients with post-stroke aphasia and 22 healthy volunteers were collected. CBF, voxel-mirrored homotopic connectivity (VMHC), CBF-VMHC correlation, and CBF/VMHC ratio maps were calculated. Between-group comparisons were performed to identify neurovascular changes, and correlation analyses were conducted to examine their relationship with the comprehension domain. The correlation between CBF and VMHC of the global gray matter decreased in patients with post-stroke aphasia. The total speech comprehension score was significantly associated with VMHC in the peri-Wernicke area [posterior superior temporal sulcus (pSTS): r = 0.748, p = 0.001; rostroventral area 39: r = 0.641, p = 0.008]. The decreased CBF/VMHC ratio was also mainly associated with the peri-Wernicke temporoparietal areas. Additionally, a negative relationship between the mean CBF/VMHC ratio of the cingulate gyrus subregion and sentence-level comprehension was observed (r = −0.658, p = 0.006). These findings indicate the contribution of peri-Wernicke homotopic functional connectivity to speech comprehension and reveal that abnormal neurovascular coupling of the cingulate gyrus subregion may underly comprehension deficits in patients with post-stroke aphasia.
Funder
Natural Science Foundation of Zhejiang Province
National Natural Science Foundation of China
Medical Science and Technology Project of Zhejiang Province
Publisher
Frontiers Media SA
Subject
Cognitive Neuroscience,Aging
Cited by
1 articles.
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