Author:
Kurihara Shigekazu,Sawa Naoki,Sumida Keiichi,Ikuma Daisuke,Oba Yuki,Mizuno Hiroki,Sekine Akinari,Yamanouchi Masayuki,Hasegawa Eiko,Suwabe Tatsuya,Urakami Shinji,Kono Kei,Kinowaki Keiichi,Ohashi Kenichi,Yamaguchi Yutaka,Ubara Yoshifumi
Abstract
A kidney biopsy was performed in a 64-year-old woman with type 2 diabetes mellitus and less than 1 g of proteinuria who rapidly progressed to end-stage renal failure after approximately 2 years of treatment with two dipeptidyl peptidase 4 (DPP-4) inhibitors for type 2 diabetes mellitus. The biopsy revealed not only a coincidental diagnosis of renal cell carcinoma, which was not evident on pre-biopsy computed tomography, but also severe thrombotic microangiopathy (TMA)-like glomerular endothelial cell damage in the noncancerous areas. These results suggest that DPP4 inhibitors may have been involved in two kidney diseases.