Author:
Zhao Weinan,Li Qing,Ma Yu,Wang Zhiyong,Fan Bingqian,Zhai Xiaojing,Hu Mengfan,Wang Qing,Zhang Moruo,Zhang Chunyan,Qin Yixue,Sha Sha,Gan Zhonghao,Ye Fan,Xia Yihan,Zhang Guangchao,Yang Li,Zou Shiya,Xu Zheng,Xia Sunhui,Yu Yumei,Abdul Mannan,Yang Jun-Xia,Cao Jun-Li,Zhou Fang,Zhang Hongxing
Abstract
Robust sex difference among humans regarding psychiatry- and pain-related behaviors is being researched; however, the use of female mice in preclinical research is relatively rare due to an unchecked potential behavioral variation over the estrous cycle. In the present study, a battery of psychiatry- and pain-related behaviors are examined under physiological condition in female C57BL/6J mice over different estrous cycle phases: proestrus, estrous, metestrous, diestrous. Our behavioral results reveal that there is no significant difference over different phases of the estrous cycle in social interaction test, sucrose preference test, tail suspension test, open field test, marble burying test, novelty-suppressed feeding test, Hargreaves thermal pain test, and Von Frey mechanical pain test. These findings implicate those psychiatry- and pain-related behaviors in normal female C57BL/6J mice appear to be relatively consistent throughout the estrous cycle; the estrous cycle might not be a main contributor to female C57BL/6J mice’s variability of behaviors.
Reference59 articles.
1. Marble burying and nestlet shredding as tests of repetitive, compulsive-like behaviors in mice.;Angoa-Pérez;J. Vis. Exp.,2013
2. Ventral hippocampal afferents to the nucleus accumbens regulate susceptibility to depression.;Bagot;Nat. Commun.,2015
3. Female rats are not more variable than male rats: a meta-analysis of neuroscience studies.;Becker;Biol. Sex Differ.,2016
4. Exposure to repeated maternal aggression induces depressive-like behavior and increases startle in adult female rats.;Bourke;Behav. Brain Res.,2012
5. Behavioural correlates of the oestrous cycle in the rat.;Burke;Nature,1966
Cited by
16 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献