Causal association of immune cells and endometriosis: a Mendelian randomization study

Author:

Fang Xingyi,Deng Qinghua,Yang Haili,Yan Zhaohua,Peng Zhen,Zhao Yuheng,Liao Tantan,Tu Ziying,Liu Jia,Liu Li,Zou Lin,He Honghua

Abstract

ObjectiveTo investigate the causal effect of immune cells on endometriosis (EMS), we performed a Mendelian randomization analysis.MethodsMendelian randomization (MR) uses genetic variants as instrumental variables to investigate the causal effects of exposures on outcomes in observational data. In this study, we conducted a thorough two-sample MR analysis to investigate the causal relationship between 731 immune cells and endometriosis. We used complementary Mendelian randomization (MR) methods, including weighted median estimator (WME) and inverse variance weighted (IVW), and performed sensitivity analyses to assess the robustness of our results.ResultsFour immune phenotypes have been found to be significantly associated with the risk of developing EMS: B cell %lymphocyte (WME: OR: 1.074, p = 0.027 and IVW: OR: 1.058, p = 0.008), CD14 on Mo MDSC (WME: OR: 1.056, p =0.021 and IVW: OR: 1.047, p = 0.021), CD14+ CD16− monocyte %monocyte (WME: OR: 0.947, p = 0.024 and IVW: OR: 0.958, p = 0.011), CD25 on unsw mem (WME: OR: 1.055, p = 0.030 and IVW: OR: 1.048, p = 0.003). Sensitivity analyses confirmed the main findings, demonstrating consistency across analyses.ConclusionsOur MR analysis provides compelling evidence for a direct causal link between immune cells and EMS, thereby advancing our understanding of the disease. It also provides new avenues and opportunities for the development of immunomodulatory therapeutic strategies in the future.

Publisher

Frontiers Media SA

Reference64 articles.

1. ESHRE guideline for the diagnosis and treatment of endometriosis;Kennedy;Hum Reprod,2005

2. Antioxidant supplementation reduces endometriosis-related pelvic pain in humans;Santanam;Trans Res,2013

3. Epigenetics of endometriosis;Guo;Mol Hum Reprod,2009

4. The effect of hormones on endometriosis development;Barbosa;Minerva Ginecol,2011

5. Environmental influences on the development of endometriosis;Carmona;J Endometriosis Pelvic Pain Disord,2013

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