Increased sLRP1 and decreased atrial natriuretic peptide plasma levels in newly diagnosed T2DM patients are normalized after optimization of glycemic control

Author:

García Eduardo,Gil Pedro,Miñambres Inka,Benitez-Amaro Aleyda,Rodríguez Claudia,Claudi Lene,Julve Josep,Benitez Sonia,Sánchez-Quesada Jose Luís,Rives Jose,Garcia-Moll Xavier,Vilades David,Perez Antonio,Llorente-Cortes Vicenta

Abstract

BackgroundLow-density lipoprotein receptor-related protein 1 (LRP1) negatively modulates circulating atrial natriuretic peptide (ANP) levels. Both molecules are involved in the regulation of cardiometabolism.ObjectivesTo evaluate soluble LRP1 (sLRP1) and ANP levels in people with newly diagnosed type 2 diabetes mellitus (T2DM) and determine the effects of metabolic optimization.MethodsThis single-center longitudinal observational study recruited patients with newly diagnosed T2DM (n = 29, HbA1c > 8.5%), and 12 healthy control, age- and sex-matched volunteers. sLRP1 and ANP levels were measured by immunoassays at T2DM onset and at one year after optimization of glycemic control (HbA1c ≤ 6.5%).ResultsT2DM had higher sLRP1 levels than the control group (p = 0.014) and lower ANP levels (p =0.002). At 12 months, 23 T2DM patients reached the target of HbA1c ≤ 6.5%. These patients significantly reduced sLRP1 and increased ANP levels. Patients who did not achieve HbA1c < 6.5% failed to normalize sLRP1 and ANP levels. There was an inverse correlation in the changes in sLRP1 and ANP (p = 0.031). The extent of sLRP1 changes over 12 months of metabolic control positively correlated with those of total cholesterol, LDL cholesterol, TG, TG/HDLc, and apolipoprotein B.ConclusionsNewly diagnosed T2DM patients have an increased sLRP1/ANP ratio, and increased sLRP1 and decreased ANP levels are normalized in the T2DM patients that reached an strict glycemic and metabolic control. sLRP1/ANP ratio could be a reliable marker of cardiometabolic function.

Funder

Instituto de Salud Carlos III

Fundación BBVA

Fundació la Marató de TV3

Centro de Investigación Biomédica en Red Enfermedades Cardiovasculares

Centro de Investigación Biomédica en Red Diabetes y Enfermedades Metabólicas Asociadas

Ministerio de Economía y Competitividad

Publisher

Frontiers Media SA

Subject

Endocrinology, Diabetes and Metabolism

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