Author:
Richard Allison J.,Hang Hardy,Allerton Timothy D.,Zhao Peng,Mendoza Tamra,Ghosh Sujoy,Elks Carrie M.,Stephens Jacqueline M.
Abstract
STATs (Signal Transducers and Activators of Transcription) 5A and 5B are induced during adipocyte differentiation and are primarily activated by growth hormone (GH) and prolactin in fat cells. Previous studies in mice lacking adipocyte GH receptor or STAT5 support their roles in lipolysis-mediated reduction of adipose tissue mass. Male and female mice harboring adipocyte-specific deletion of both STAT5 genes (STAT5AKO) exhibit increased subcutaneous or inguinal adipose tissue mass, but no changes in visceral or gonadal fat mass. Both depots display substantial increases in adipocyte size with no changes in lipolysis in adipose tissue explants. RNA sequencing analysis of subcutaneous adipose tissue and indirect calorimetry experiments reveal sex-dependent differences in adipose gene expression and whole-body energy expenditure, respectively, resulting from the loss of adipocyte STAT5.
Funder
National Institute of Diabetes and Digestive and Kidney Diseases
National Institutes of Health
Subject
Endocrinology, Diabetes and Metabolism
Reference67 articles.
1. Metabolically Healthy Obesity: The Low-Hanging Fruit in Obesity Treatment;Stefan;Lancet Diabetes Endocrinol,2018
2. Subcutaneous Adipose Tissue Accumulation Protects Systemic Glucose Tolerance and Muscle Metabolism;Booth;Adipocyte,2018
3. Comparing Adiposity Profiles in Three Mouse Models With Altered GH Signaling;Berryman;Growth Horm IGF Res,2004
4. Increased Insulin Sensitivity and Upregulation of Insulin Receptor, Insulin Receptor Substrate (IRS)-1 and IRS-2 in Liver of Ames Dwarf Mice;Dominici;J Endocrinol,2002
5. Deletion, But Not Antagonism, of the Mouse Growth Hormone Receptor Results in Severely Decreased Body Weights, Insulin, and Insulin-Like Growth Factor I Levels and Increased Life Span;Coschigano;Endocrinology,2003
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