Author:
Long Zhiyong,Deng Ying,He Qi,Yang Kailin,Zeng Liuting,Hao Wensa,Deng Yuxuan,Fan Jiapeng,Chen Hua
Abstract
ObjectiveTo explore the efficacy and safety of Iguratimod (IGU) intervention in the treatment of Ankylosing Spondylitis (AS).MethodsWe used computer to search literature databases, collected randomized controlled trials (RCTs) related to IGU treatment of AS, and searched the relevant literature in each database until Sep. 2022. Two researchers independently carried out literature screening, data extraction, and evaluation and analysis of the risk of bias in the included studies, and then used Rev Man5.3 software for meta-analysis. The protocol is CRD42020220798.ResultsA total of 10 RCTs involves in 622 patients were collected. The statistical analysis showed that IGU can decrease the BASDAI score (SMD -1.62 [-2.20, -1.05], P<0.00001. Quality of evidence: low), the BASFI score (WMD -1.30 [-1.48, -1.12], P<0.00001. Quality of evidence: low) and the VAS (WMD -2.01 [-2.83, -1.19], P<0.00001. Quality of evidence: very low). Meanwhile, the addition of IGU into the conventional therapy would not increase the adverse events (RR 0.65 [0.43, 0.98], P=0.04. Quality of evidence: moderate).ConclusionIGU may be an effective and safe intervention for AS. Systematic review registrationhttps://www.crd.york.ac.uk/prospero/display_record.php?, identifier CRD42020220798.
Subject
Immunology,Immunology and Allergy
Cited by
2 articles.
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