Author:
Li Lili,Li Jie,Gao Meiling,Fan Huimin,Wang Yanan,Xu Xin,Chen Chunfeng,Liu Junxiao,Kim Jocelyn,Aliyari Roghiyh,Zhang Jicai,Jin Yujie,Li Xiaorong,Ma Feng,Shi Minxin,Cheng Genhong,Yang Heng
Abstract
The widespread prevalence of coronavirus disease-2019 (COVID-19) which is caused by severe respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, has resulted in a severe global public health emergency. However, there are no sensitive biomarkers to predict the disease prognosis of COVID-19 patients. Here, we have identified interleukin-8 (IL-8) as a biomarker candidate to predict different disease severity and prognosis of COVID-19 patients. While serum IL-6 become obviously elevated in severe COVID-19 patients, serum IL-8 was easily detectible in COVID-19 patients with mild syndromes. Furthermore, lL-8 levels correlated better than IL-6 levels with the overall clinical disease scores at different stages of the same COVID-19 patients. Thus, our studies suggest that IL-6 and IL-8 can be respectively used as biomarkers for severe COVID-19 patients and for COVID-19 disease prognosis.
Subject
Immunology,Immunology and Allergy
Cited by
97 articles.
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