Author:
Wang Yicun,Sheng Jiyao,Chai Jin,Zhu Cuilin,Li Xin,Yang Wei,Cui Ranji,Ge Tongtong
Abstract
Glioma is a life-threatening malignant tumor. Resistance to traditional treatments and tumor recurrence present major challenges in treating and managing this disease, consequently, new therapeutic strategies must be developed. Crossing the blood-brain barrier (BBB) is another challenge for most drug vectors and therapy medications. Filamentous bacteriophage can enter the brain across the BBB. Compared to traditional drug vectors, phage-based drugs offer thermodynamic stability, biocompatibility, homogeneity, high carrying capacity, self-assembly, scalability, and low toxicity. Tumor-targeting peptides from phage library and phages displaying targeting peptides are ideal drug delivery agents. This review summarized recent studies on phage-based glioma therapy and shed light on the developing therapeutics phage in the personalized treatment of glioma.
Funder
Foundation for Innovative Research Groups of the National Natural Science Foundation of China
Department of Science and Technology of Jilin Province
Department of Finance of Jilin Province
Education Department of Jilin Province
National Key Research and Development Program of China
Subject
Immunology,Immunology and Allergy
Cited by
12 articles.
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