Author:
Chen Yukun,Liu Yujun,Chen Shimin,Zhang Long,Rao Jiawei,Lu Xinjun,Ma Yi
Abstract
Primary liver cancer (PLC) is one type of cancer with high incidence rate and high mortality rate in the worldwide. Systemic therapy is the major treatment for PLC, including surgical resection, immunotherapy and targeted therapy. However, mainly due to the heterogeneity of tumors, responses to the above drug therapy differ from person to person, indicating the urgent needs for personalized treatment for PLC. Organoids are 3D models derived from adult liver tissues or pluripotent stem cells. Based on the ability to recapitulate the genetic and functional features of in vivo tissues, organoids have assisted biomedical research to make tremendous progress in understanding disease origin, progression and treatment strategies since their invention and application. In liver cancer research, liver organoids contribute greatly to reflecting the heterogeneity of liver cancer and restoring tumor microenvironment (TME) by co-organizing tumor vasculature and stromal components in vitro. Therefore, they provide a promising platform for further investigation into the biology of liver cancer, drug screening and precision medicine for PLC. In this review, we discuss the recent advances of liver organoids in liver cancer, in terms of generation methods, application in precision medicine and TME modeling.
Funder
Natural Science Foundation of Guangdong Province
National Natural Science Foundation of China
Science and Technology Planning Project of Guangdong Province
Guangzhou Municipal Science and Technology Project
Guangdong Provincial Key Laboratory of Construction Foundation
Subject
Immunology,Immunology and Allergy
Cited by
2 articles.
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