Abstract
When the external conditions change, such as the temperature or the pressure, the multi-component system sometimes separates into several phases with different components and structures, which is called phase separation. Increasing studies have shown that cells condense related biomolecules into independent compartments in order to carry out orderly and efficient biological reactions with the help of phase separation. Biomolecular condensates formed by phase separation play a significant role in a variety of cellular processes, including the control of signal transduction, the regulation of gene expression, and the stress response. In recent years, many phase separation events have been discovered in the immune response process. In this review, we provided a comprehensive and detailed overview of the role and mechanism of phase separation in the innate and adaptive immune responses, which will help the readers to appreciate the advance and importance of this field.
Funder
National Natural Science Foundation of China
Subject
Immunology,Immunology and Allergy
Reference139 articles.
1. Biomolecular condensates: Organizers of cellular biochemistry;Banani;Nat Rev Mol Cell Biol,2017
2. Phase separation in biology; functional organization of a higher order;Mitrea;Cell Commun Signal,2016
3. The control centers of biomolecular phase separation: How membrane surfaces, PTMs, and active processes regulate condensation;Snead;Mol Cell,2019
4. A conceptual framework for understanding phase separation and addressing open questions and challenges;Mittag;Mol Cell,2022
5. Cajal bodies, nucleoli, and speckles in the xenopus oocyte nucleus have a low-density, sponge-like structure;Handwerger;Mol Biol Cell,2005
Cited by
3 articles.
订阅此论文施引文献
订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献