Author:
Xu Wen,Wan Sheng,Xie Bo,Song Xiuzu
Abstract
Alopecia areata (AA) is a non-scarring hair loss disorder caused by autoimmunity. The immune collapse of the hair follicle, where interferon-gamma (IFN-γ) and CD8+ T cells accumulate, is a key factor in AA. However, the exact functional mechanism remains unclear. Therefore, AA treatment has poor efficacy maintenance and high relapse rate after drug withdrawal. Recent studies show that immune-related cells and molecules affect AA. These cells communicate through autocrine and paracrine signals. Various cytokines, chemokines and growth factors mediate this crosstalk. In addition, adipose-derived stem cells (ADSCs), gut microbiota, hair follicle melanocytes, non-coding RNAs and specific regulatory factors have crucial roles in intercellular communication without a clear cause, suggesting potential new targets for AA therapy. This review discusses the latest research on the possible pathogenesis and therapeutic targets of AA.
Funder
Basic Public Welfare Research Program of Zhejiang Province
Subject
Immunology,Immunology and Allergy
Reference145 articles.
1. Alopecia areata: disease characteristics, clinical evaluation, and new perspectives on pathogenesis;Strazzulla;J Am Acad Dermatol,2018
2. Epidemiology of alopecia areata, ophiasis, totalis, and universalis: a systematic review and meta-analysis;Lee;J Am Acad Dermatol,2020
3. The alopecia areata consensus of experts (ACE) study part II: results of an international expert opinion on diagnosis and laboratory evaluation for alopecia areata;Meah;J Am Acad Dermatol,2021
4. Development of the alopecia areata scale for clinical use: results of an academic-industry collaborative effort;King;J Am Acad Dermatol,2022
5. Hair regrowth outcomes of contact immunotherapy for patients with alopecia areata: a systematic review and meta-analysis;Lee;JAMA Dermatol,2018
Cited by
1 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献