Author:
Meng Lu,Xu Jianfang,Ye Ying,Wang Yingying,Luo Shilan,Gong Xiaomei
Abstract
Radiotherapy is an effective local treatment modality of NSCLC. Its capabilities of eliminating tumor cells by inducing double strand DNA (dsDNA) damage and modulating anti-tumor immune response in irradiated and nonirradiated sites have been elucidated. The novel ICIs therapy has brought hope to patients resistant to traditional treatment methods, including radiotherapy. The integration of radiotherapy with immunotherapy has shown improved efficacy to control tumor progression and prolong survival in NSCLC. In this context, biomarkers that help choose the most effective treatment modality for individuals and avoid unnecessary toxicities caused by ineffective treatment are urgently needed. This article summarized the effects of radiation in the tumor immune microenvironment and the mechanisms involved. Outcomes of multiple clinical trials investigating immuno-radiotherapy were also discussed here. Furthermore, we outlined the emerging biomarkers for the efficacy of PD-1/PD-L1 blockades and radiation therapy and discussed their predictive value in NSCLC.
Funder
Scientific and Innovative Action Plan of Shanghai
Foundation for Innovative Research Groups of the National Natural Science Foundation of China
Shanghai Pulmonary Hospital
Natural Science Foundation of Shanghai
Subject
Immunology,Immunology and Allergy
Cited by
17 articles.
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