Immune checkpoints on T and NK cells in the context of HBV infection: Landscape, pathophysiology and therapeutic exploitation

Author:

Dumolard Lucile,Aspord Caroline,Marche Patrice N.,Macek Jilkova Zuzana

Abstract

In hepatitis B virus (HBV) infection, the interplay between the virus and the host immune system is crucial in determining the pathogenesis of the disease. Patients who fail to mount a sufficient and sustained anti-viral immune response develop chronic hepatitis B (CHB). T cells and natural killer (NK) cells play decisive role in viral clearance, but they are defective in chronic HBV infection. The activation of immune cells is tightly controlled by a combination of activating and inhibitory receptors, called immune checkpoints (ICs), allowing the maintenance of immune homeostasis. Chronic exposure to viral antigens and the subsequent dysregulation of ICs actively contribute to the exhaustion of effector cells and viral persistence. The present review aims to summarize the function of various ICs and their expression in T lymphocytes and NK cells in the course of HBV infection as well as the use of immunotherapeutic strategies targeting ICs in chronic HBV infection.

Funder

Horizon 2020

Publisher

Frontiers Media SA

Subject

Immunology,Immunology and Allergy

Reference210 articles.

1. Hepatitis b2022

2. Hepatitis b virus biology and life cycle;Tsukuda;Antiviral Res,2020

3. Recent advances in vaccination of non-responders to standard dose hepatitis b virus vaccine;Walayat;World J hepatol,2015

4. Three decades of hepatitis b control with vaccination;Meireles;World J hepatol,2015

5. Hepatitis b vaccines;Pattyn;J Infect Dis,2021

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