Three-Component Synthesis of Some New Coumarin Derivatives as Anticancer Agents-Reference-Cited by-同舟云学术

Three-Component Synthesis of Some New Coumarin Derivatives as Anticancer Agents

Published:2022-01-25 Issue: Volume:9 Page:
ISSN:2296-2646
Container-title:Frontiers in Chemistry
language:
Short-container-title:Front. Chem.

Author:

Alshabanah Latifah A.,Al-Mutabagani Laila A.,Gomha Sobhi M.,Ahmed Hoda A.

Abstract

A three-component reaction for the synthesis of novel 3-heteroaryl-coumarin utilizing acetylcoumarin synthon under ultrasonic irradiation was developed using chitosan-grafted poly(vinylpyridine) as an eco-friendly catalyst. The process is a simple, facile, efficient procedure for the preparation of compounds displaying a thiazole ring linked to coumarin moiety. Moreover, all the products were evaluated for their anticancer activities against HEPG2-1. The results revealed that three new compounds showed promising anticancer activities.

Publisher

Frontiers Media SA

Subject

General Chemistry

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