Interactions between vaginal local cytokine IL-2 and high-risk human papillomavirus infection with cervical intraepithelial neoplasia in a Chinese population-based study
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Published:2023-05-15
Issue:
Volume:13
Page:
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ISSN:2235-2988
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Container-title:Frontiers in Cellular and Infection Microbiology
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language:
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Short-container-title:Front. Cell. Infect. Microbiol.
Author:
Zhu Ruoxi,Wang Wenhao,Yang Aiming,Zhao Weihong,Wang Wei,Wang Zhilian,Wang Jintao,Hou Yongli,Su Xiaoqiang,Zhang Lili,Feng Bo,Yang Jing,Wang Zhe,Niu Xiaofen,Lv Weiguo,Qu Zhican,Hao Min
Abstract
BackgroundAlthough interleukin-2 (IL-2) has long been associated with cancer development, its roles in the development of cervical cancer remains unclear. Few studies examined the associations between IL-2 and high-risk human papillomavirus (HPV) with risk of cervical intraepithelial neoplasia (CIN).ObjectiveWe aimed to assess the association of IL-2 and high-risk HPV infection with risk of CIN as well as their interactions on the risk of CIN.DesignWe performed a cross-sectional analysis of screening data in 2285 women aged 19-65 years who participated in an ongoing community-based cohort of 40,000 women in Shanxi, China in 2014-2015. Both categorical and spline analyses were used to evaluation the association between IL-2 in the local vaginal fluids and prevalence of CIN. In addition, 1503 controls were followed up until January 31, 2019), the nested case-control study design was adopted to evaluate the association of vaginal lavage IL-2 levels and the risk of CIN progression.ResultsAfter adjusting for potential confounders, IL-2 levels were statistically inversely associated with prevalence of CIN (the 1st versus 4th quartile IL-2 levels: the respective odds ratio [OR] and 95% confidence intervals [CI] was: = 1.75 [1.37, 2.23] for CIN, 1.32 [1.01, 1.73] for CIN I, and 3.53 [2.26, 5.52] for CIN II/III). Increased IL-2 levels were inversely associated with prevalence of CIN (P-overall<0.01, P-nonlinearity<0.01 for CIN; P-overall<0.01, P-nonlinearity = 0.01 for CIN I; P-overall <0.01, P-nonlinearity = 0.62 for CIN II/III). The highest prevalence of CIN was observed in women with high-risk HPV, who also had the lowest IL-2 levels (P-interaction < 0.01). Nested case-control study observed an inverse association between IL-2 levels and risk of CIN progression (OR=3.43, [1.17, 10.03]).ConclusionsIL-2 levels in the local vaginal fluids were inversely associated with the risk of CIN in Chinese women either with or without high-risk HPV infection.
Funder
National Health and Family Planning Commission of the People's Republic of China
National Natural Science Foundation of China
Shanxi Provincial Key Research and Development Project
Publisher
Frontiers Media SA
Subject
Infectious Diseases,Microbiology (medical),Immunology,Microbiology
Cited by
1 articles.
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