Author:
Lu Wei,Li Peng,Wen Wu,Jian Yi
Abstract
BackgroundEndoscopic dissection (ED) shows relatively high clinical value in early esophageal cancer (cT1N0) such as lower incidence of postoperative complications and hospitalization costs and enhanced recovery. However, whether ED still has certain advantages over esophagectomy in terms of long-term survival remains unclear.PurposeThe aim of this meta-analysis was to compare the long-term outcomes of ED and surgery in the treatment of cT1N0 esophageal cancer.MethodsSeveral electronic databases including the PubMed, EMBASE, Web of Science and Cochrane Library databases were searched up to April 7, 2022 for studies which compared the overall survival (OS) and disease-specific survival (DSS) of cT1N0 esophageal cancer patients receiving the ED or esophagectomy. The hazard ratios (HRs) and 95% confidence intervals (CIs) were combined and all statistical analysis was conducted through STATA 15.0 software.ResultsA total of 12 studies involving 3,732 patients were enrolled. No significant difference in the OS between ED and surgery groups was observed (HR = 0.78, 95% CI, 0.59–1.04, p = 0.089). However, the DSS of the ED group was significantly longer than that of the surgery group (HR = 0.56, 95% CI, 0.39–0.82, p = 0.003).ConclusionIn overall, the current evidence manifested that the long-term survival of cT1N0 esophageal cancer patients undergoing ED was not worse than that of patients undergoing esophagectomy. ED may be considered as the primary treatment for cT1N0 esophageal carcinoma patients.
Reference40 articles.
1. Cancer statistics for African American/Black People 2022;Giaquinto;CA Cancer J Clin,2022
2. Cancer statistics in Korea: incidence, mortality, survival, and prevalence in 2019;Kang;Cancer Res Treat,2022
3. Cancer statistics in China and United States, 2022: profiles, trends, and determinants;Xia;Chin Med J (Engl),2022
4. The impact of initial treatment strategy and survival time on quality of end-of-life care among patients with oesophageal and gastric cancer: a population-based cohort study;Dalhammar;PLoS One,2020
5. Future treatment strategy for esophageal cancer based on prediction of systemic recurrence: significance of pathologic nodal status after neoadjuvant chemotherapy;Yasuda;Ann Surg Oncol,2018
Cited by
2 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献