Changes in gut microbiota composition after 12 weeks of a home-based lifestyle intervention in breast cancer survivors during the COVID-19 lockdown

Author:

Donati Zeppa Sabrina,Natalucci Valentina,Agostini Deborah,Vallorani Luciana,Amatori Stefano,Sisti Davide,Rocchi Marco B. L.,Pazienza Valerio,Perri Francesco,Villani Annacandida,Binda Elena,Panebianco Concetta,Mencarelli Gandino,Ciuffreda Luigi,Ferri Marini Carlo,Annibalini Giosué,Lucertini Francesco,Bartolacci Alessia,Imperio Marta,Virgili Edy,Catalano Vincenzo,Piccoli Giovanni,Stocchi Vilberto,Emili Rita,Barbieri Elena

Abstract

BackgroundBreast cancer (BC) is the second-leading cause of cancer-related death worldwide. This study aimed to investigate the effects of a 12-week home-based lifestyle intervention (based on nutrition and exercise) on gut microbial composition in twenty BC survivors of the MoviS clinical trial (protocol: NCT 04818359).MethodsGut microbiota analysis through 16S rRNA gene sequencing, anthropometrics, Mediterranean Diet (MD) adherence, and cardiometabolic parameters were evaluated before (Pre) and after (Post) the lifestyle intervention (LI).ResultsBeneficial effects of the LI were observed on MD adherence, and cardiometabolic parameters (pre vs post). A robust reduction of Proteobacteria was observed after LI, which is able to reshape the gut microbiota by modulating microorganisms capable of decreasing inflammation and others involved in improving the lipid and glycemic assets of the host. A significant negative correlation between fasting glucose and Clostridia_vadinBB60 (r = -0.62), insulin and homeostatic model assessment (HOMA) index and Butyricicoccus genera (r = -0.72 and -0.66, respectively), and HDL cholesterol and Escherichia/Shigella (r = -0.59) have been reported. Moreover, positive correlations were found between MD adherence and Lachnospiraceae_ND3007 (r = 0.50), Faecalibacterium (r = 0.38) and Butyricimonas (r = 0.39).ConclusionThese data suggest that adopting a healthy lifestyle, may contribute to ameliorate several biological parameters that could be involved in the prevention of cancer relapses through the modulation of gut microbiota.

Publisher

Frontiers Media SA

Subject

Cancer Research,Oncology

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