Author:
Miserocchi Giacomo,Bassi Massimo,De Luca Giovanni,Calpona Sebastiano,De Rosa Francesco,Bongiovanni Alberto,Parisi Elisabetta,Di Menna Giandomenico,De Vita Alessandro,Liverani Chiara,Spadazzi Chiara,Cocchi Claudia,Vanni Silvia,Capelli Laura,Magnani Massimo,Meccariello Giuseppe,Vicini Claudio,Campobassi Angelo,Mercatali Laura,Ibrahim Toni
Abstract
BackgroundPolymorphous adenocarcinoma (PAC) represents the second most widespread neoplasm of the minor salivary glands. These tumors rarely develop a histological progression from low-grade to high-grade malignancy, named “high-grade transformation” (HGT). Only nine cases are described in literature.Case descriptionHere, we describe the case of a 76-year-old male patient with a PAC recurrence of the oral floor displaying HGT, and we explore the tumor cytomorphological features, genomic profiling, and the patient’s clinical management. The tumor mass was characterized by poorly atypical cellular elements with vesicular nuclei and comedonecrosis foci. The growth pattern was predominantly solid, tubular, and cribriform. The lesion did not show microsatellite instability or targeted molecular alterations. The case was successfully treated with radical surgery followed by radiotherapy.ConclusionWe report for the first time the recurrence of a PAC with HGT arising in the oral floor after 20 years from the primary lesion. These preliminary data and the literature analysis enhance the knowledge of this extremely rare disease.