Author:
Liang Zuoyu,Zhou Ping,Wang Yuxuan,Zhang Ying,Li Dan,Su Xiaoxing,Fan Yu,Tang Yuan,Jiang Lili,Wang Weiya
Abstract
IntroductionPulmonary adenofibroma (PAF), characterized by biphasic differentiation composed of gland-like space lined by respiratory epithelium and stromal spindle cells, is a rare benign tumor of the lung. PAF was reported infrequently and inconsistently with diagnostic criteria and withstood higher risk of misdiagnosis as solitary fibrous tumors (SFTs) due to their morphological resemblance. In this study, we report seven cases of PAF with gene sequencing results and summarize the data of previous literature.Materials and MethodsSeven cases of PAF with surgically resection samples were collected from Pathology department of West China Hospital, Sichuan University between 2009 to 2020. Immunohistochemical studies were performed in all cases and 3 cases underwent a 425-gene panel next-generation sequencing (NGS).ResultsFive female and two male patients were included in this study, with an average age of 51 years. All the patients were asymptomatic, and the lesion was identified on routine chest radiography. The tumor size measured by computed tomography (CT) ranged from 0.5 to 2.7 cm. Gland-like structures were mostly positive for glandular epithelium markers. The spindle cells in stroma expressed Desmin, SMA, ER and PR in 3 of 7 cases. No well-recognized molecular abnormalities can be identified by NGS in the 3 cases. To date, all the patients are alive, with no evidence of recurrence and metastasis.ConclusionPAF is a unique benign pulmonary tumor with low incidence. Biphasic morphology, IHC stains along with molecular detection is of great significance to make a clear diagnosis.
Reference38 articles.
1. Fibroadenoma of the Lung;Scarff;J Pathol Bacteriol,1944
2. Solitary Fibrous Pseudopapillary Tumor of the Lung: Pulmonary Fibroadenoma and Adenofibroma Revisited;Cavazza;Pathologica,2003
3. Adenofibromatous Pattern in a Solitary Fibrous Tumor of the Lung;Sironi;Int J Surg Pathol,2005
4. Recurrent NAB2-STAT6 Gene Fusions and Oestrogen Receptor-α Expression in Pulmonary Adenofibromas;Fusco;Histopathology,2017
Cited by
1 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献