Author:
Wang Ting,Li Zhaosheng,Yan Liujia,Yan Feng,Shen Han,Tian Xinyu
Abstract
Long non-coding RNAs (lncRNAs) are involved in fundamental biochemical and cellular processes. The neighbor of BRCA1 gene 2 (NBR2) is a long intergenic non-coding RNA (lincRNA) whose gene locus is adjacent to the tumor suppressor gene breast cancer susceptibility gene 1 (BRCA1). In human cancers, NBR2 expression is dysregulated and correlates with clinical outcomes. Moreover, NBR2 is crucial for glucose metabolism and affects the proliferation, survival, metastasis, and therapeutic resistance in different types of cancer. Here, we review the precise molecular mechanisms underlying NBR2-induced changes in cancer. In addition, the potential application of NBR2 in the diagnosis and treatment of cancer is also discussed, as well as the challenges of exploiting NBR2 for cancer intervention.
Funder
National Natural Science Foundation of China-China Academy of General Technology Joint Fund for Basic Research
Natural Science Foundation of Jiangsu Province
Jiangsu Postdoctoral Research Foundation
China Postdoctoral Science Foundation
Cited by
2 articles.
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