Author:
Ding Yezhou,Feng Mingyang,Ma Di,Zhao Gangde,Wang Xiaolin,An Baoyan,Xu Yumin,Lou Shike,Lin Lanyi,Xie Qing,Liu Kehui,Bao Shisan,Wang Hui
Abstract
BackgroundThe clinical characteristics of primary liver cancer (PLC) patients are changing, maybe due to hepatitis viral vaccination and lifestyle changes, etc. The linkage between these changes and outcomes among these PLCs has not yet been fully elucidated.MethodsIt was identified total of 1691 PLC cases diagnosed between 2000 ~ 2020. Cox proportional hazards models were utilized to determine the connections between the clinical presentations and their close risk factor(s) from PLC patients.ResultsThe average age of PLC patients increased gradually from 52.74 ± 0.5 years in 2000 ~ 2004 to 58.63 ± 0.44 years in 2017 ~ 2020, accompanied by an increased proportion of females from 11.11% to 22.46%, and non-viral hepatitis-related PLC was raised from 1.5% to 22.35%. 840 (49.67%) PLC patients with alpha-fetoprotein (AFP) < 20ng/mL (AFP-negative). The mortality was 285 (16.85%) or 532 (31.46%) PLC patients with alanine transaminase (ALT) between 40 ~ 60 IU/L or ALT > 60 IU/L. The PLC patients with pre-diabetes/diabetes or dyslipidemia also increased from 4.29% or 11.1% in 2000 ~ 2004 to 22.34% or 46.83% in 2017 ~ 2020. The survival period of the PLC patients with normoglycemia or normolipidemic was 2.18 or 3.14 folds longer than those patients with pre-diabetes/diabetes or hyperlipidemia (P<0.05).ConclusionsIt was gradually increased that age, the proportion of females, non-viral hepatitis-related causes, AFP-negative, and abnormal glucose/lipids among PLC patients. Proper control of glucose/lipids or ALT may improve the prognosis of PLCs.
Reference46 articles.
1. Hepatocellular carcinoma;Llovet;Nat Rev Dis Primers,2021
2. Global, regional, and national cancer incidence, mortality, years of life lost, years lived with disability, and disability-adjusted life-years for 29 cancer groups, 1990 to 2017: A systematic analysis for the global burden of disease study;Fitzmaurice;JAMA Oncol,2019
3. Hepatocellular carcinoma — origins and outcomes;Robin;New Engl J Med,2021
4. Anti-viral therapy is associated with improved survival but is underutilised in patients with hepatitis b virus-related hepatocellular carcinoma: Real-world East and West experience;Chen;Aliment Pharmacol Ther,2018
5. International trends in hepatocellular carcinoma incidence, 1978-2012;Petrick;Int J Cancer,2020
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