Author:
Choi Woosuk,Park Joseph Kyu-hyung,Song Seung Geun,Kim Baek-kyu
Abstract
Although epidermoid cysts are frequently seen as benign lesions, they are highly uncommon to develop into cancerous lesions. A 36-year-old man with a cystic mass present on his left flank since childhood presented to our department. Based on the patient’s medical history and abdominal computed tomography scan, we excised the lesion under the suspicion of an epidermoid cyst. Histopathological evaluation revealed the presence of poorly differentiated carcinoma with squamoid and basaloid differentiation, which showed a strong possibility of carcinoma arising from an epidermal cyst. Next-generation sequencing using TruSight oncology 500 assay showed copy number variation of ATM and CHEK1 genes.
Reference17 articles.
1. Lever's histopathology of the skin;Kirkham;Chapter.,2005
2. Squamous cell carcinoma arising on an epidermal inclusion cyst: a case presentation and review of the literature;Anton-Badiola;Actas dermo-sifiliograficas.,2010
3. Malignant transformation of retroperitoneal epidermoid cyst into squamous cell carcinoma: A case report;Rajan;J Radiol Case Rep,2019
4. Malignant transformation of intracranial epidermoid cyst;Vellutini;Br J Neurosurg,2014
5. Overview of epidermoid cyst;Hoang;Eur J Radiol Open,2019