Author:
Morelli Marco Bruno,Bongiovanni Chiara,Da Pra Silvia,Miano Carmen,Sacchi Francesca,Lauriola Mattia,D’Uva Gabriele
Abstract
Chemotherapy and targeted therapies have significantly improved the prognosis of oncology patients. However, these antineoplastic treatments may also induce adverse cardiovascular effects, which may lead to acute or delayed onset of cardiac dysfunction. These common cardiovascular complications, commonly referred to as cardiotoxicity, not only may require the modification, suspension, or withdrawal of life-saving antineoplastic therapies, with the risk of reducing their efficacy, but can also strongly impact the quality of life and overall survival, regardless of the oncological prognosis. The onset of cardiotoxicity may depend on the class, dose, route, and duration of administration of anticancer drugs, as well as on individual risk factors. Importantly, the cardiotoxic side effects may be reversible, if cardiac function is restored upon discontinuation of the therapy, or irreversible, characterized by injury and loss of cardiac muscle cells. Subclinical myocardial dysfunction induced by anticancer therapies may also subsequently evolve in symptomatic congestive heart failure. Hence, there is an urgent need for cardioprotective therapies to reduce the clinical and subclinical cardiotoxicity onset and progression and to limit the acute or chronic manifestation of cardiac damages. In this review, we summarize the knowledge regarding the cellular and molecular mechanisms contributing to the onset of cardiotoxicity associated with common classes of chemotherapy and targeted therapy drugs. Furthermore, we describe and discuss current and potential strategies to cope with the cardiotoxic side effects as well as cardioprotective preventive approaches that may be useful to flank anticancer therapies.
Subject
Cardiology and Cardiovascular Medicine
Reference297 articles.
1. Controversies in the definition of cardiotoxicity: do we care? – American college of cardiology.;Lambert;Am Coll Cardiol.,2016
2. Cardiotoxicity of anthracyclines.;Cardinale;Front Cardiovasc Med.,2020
3. Primary prevention strategies for anthracycline cardiotoxicity: a brief overview.;Menna;Chemotherapy.,2017
4. Models of heart failure based on the cardiotoxicity of anticancer drugs.;Mercurio;J Card Fail.,2016
5. Anthracycline cardiotoxicity.;Menna;Expert Opin Drug Saf.,2012
Cited by
35 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献