Author:
Cao Qiuyu,Li Mian,Wang Tiange,Chen Yuhong,Dai Meng,Zhang Di,Xu Yu,Xu Min,Lu Jieli,Wang Weiqing,Ning Guang,Bi Yufang,Zhao Zhiyun
Abstract
BackgroundEarly Vascular Aging and Supernormal Vascular Aging are two extreme phenotypes of vascular aging, and people in the two categories demonstrate distinct clinical characteristics and cardiovascular prognosis. However, the clinical implication of vascular aging categories in the Asian or Chinese population has not been investigated. We aimed to investigate the association between vascular aging categories and cardiovascular events in a Chinese cohort.MethodsWe explored the association of vascular aging categories with incident cardiovascular disease in a community cohort in Shanghai, China, which included 10,375 participants following up for 4.5 years. Vascular age was predicted by a multivariable linear regression model including classical risk factors and brachial-ankle pulse wave velocity. Early and Supernormal vascular aging groups were defined by 10% and 90% percentiles of Δ-age, which was calculated as chronological minus vascular age.ResultsWe found that cardiovascular risk significantly increased in Early [hazard ratio (HR), 1.597 (95% CI, 1.043–2.445)] and decreased in Supernormal [HR, 0.729 (95% CI, 0.539–0.986)] vascular aging individuals, comparing with normal vascular aging subjects. The associations were independent of the Framingham risk score. Early vascular aging individuals also showed an elevated risk of total mortality [HR, 2.614 (95% CI, 1.302–5.249)]. Further, the associations of vascular aging categories with cardiovascular risk were much stronger in females than in males. Vascular aging categories with different cutoff levels expressed as percentiles (10th, 20th, and 25th) of Δ-age showed similar associations with cardiovascular risk.ConclusionsIn conclusion, the vascular aging categories could identify people with different levels of cardiovascular risk in the Chinese population, particularly in women.
Funder
National Natural Science Foundation of China
Shanghai Municipal People's Government
Shanghai Shenkang Hospital Development Center
Program for Professor of Special Appointment (Eastern Scholar) at Shanghai Institutions of Higher Learning
National Key Research and Development Program of China
Shanghai Municipal Education Commission
Subject
Cardiology and Cardiovascular Medicine
Cited by
2 articles.
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