Author:
Pei Juan Hui,Gan Feng,Bai Yun He,Xing Yan Lin,Jia Jian Jun,Wang Huan
Abstract
AimPatients with unstable angina pectoris (UAP) usually present anxiety or depression during percutaneous coronary intervention (PCI). This study sought to investigate the instant and short-term effects of acupuncture for anxiety and depression in UAP patients with PCI.MethodsA total of 210 UAP patients who underwent PCI were recruited and randomly assigned (1:1:1) to acupuncture, placebo, or control groups. Enzyme-linked immunosorbent assay was used to detect the levels of fasting glucose, fasting insulin, homeostasis model assessment of insulin resistance (HOMA-IR), interleukin-6 (IL-6), high-sensitivity C-reactive protein (Hs-CRP), advanced oxidation protein products (AoPPs), and oxidized low-density lipoprotein (OX-LDL). Serial questionnaires with the Hamilton Anxiety (HAMA) scale and the Pittsburgh Sleep Quality Index were evaluated, and heart rate variability indicators were obtained.ResultsPrimary end-point: low frequency/high frequency (HF) was lower in the electroacupuncture group (p = 0.014), while standard deviation of normal-to-normal intervals, average standard deviation of normal-to-normal intervals, percentage of successive intervals that differ more than 50 ms, and HF were increased with acupuncture (p = 0.018, p = 0.043, p = 0.016, and p = 0.002, respectively). Secondary end-point: significant improvements in anxiety levels (HAMA) were observed in the three groups (p < 0.001). The fasting insulin and HOMA-IR levels were similar between the control group and the acupuncture group (p = 0.285 and p = 0.165, respectively). The levels of IL-6 and AoPPs differed among the three groups (p = 0.021 and p < 0.001, respectively). However, no significant differences were found in fasting plasma glucose, fasting c-peptide, Hs-CRP, and OX-LDL levels among the three groups (p = 0.585, p = 0.611, p = 0.902, and p = 0.756, respectively).ConclusionsIn this study, short-term acupuncture may potentially relieve clinical symptoms before PCI treatment.
Clinical Trial RegistrationClinicalTrials.gov, identifier (NCT03789344).
Subject
Cardiology and Cardiovascular Medicine
Reference36 articles.
1. Screening, referral and treatment for depression in patients with coronary heart disease;Colquhoun;Med J Aust,2013
2. Serum levels of FGF21, β-Klotho, and BDNF in stable coronary artery disease patients with depressive symptoms: a cross-sectional single-center study;Wu;Front Psychiatry,2021
3. Relationship between depressive symptoms and long-term mortality in patients with heart failure;Jiang;Am Heart J,2007
4. Contacts to general practice and antidepressant treatment initiation after screening for anxiety and depression in patients with heart disease;Larsen;Dan Med J,2016
5. Depressive symptoms, health behaviors, and risk of cardiovascular events in patients with coronary heart disease;Whooley;JAMA,2008