Clinical application of serum biomarkers for detecting and monitoring of chronic plaque psoriasis

Author:

Cruz Criselda Jean G.,Yang Chao-Chun

Abstract

Psoriasis, a chronic, multisystemic inflammatory disease affecting millions of people globally, manifests as erythematous, thick, scaly plaques on the skin. Clinical evaluation remains to be the benchmark for diagnosis and monitoring of this debilitating disease. With current advancements in targeted molecular therapy for psoriasis such as biologics, molecular detection methods may also help guide clinical decisions and therapeutic strategies through quantification of circulating biomarkers, which could reflect the underlying pathogenic events happening at a certain point of the disease course. In this review, we will discuss how biomarkers are detected in serum samples using enzyme-linked immunosorbent assay (ELISA). This review will feature candidate biomarkers supported by clinical data for psoriasis including, but not limited to, cytokines, chemokines, adipokines, and antimicrobial peptides. A better understanding of the common method used for biomarker detection would enable physicians to interpret and correlate laboratory results with the disease pathogenesis and clinical outcomes, e.g., severity assessment and/or therapeutic response. With better health outcomes as the main goal, the utility of such information to evaluate and even predict treatment response would be a major step closer towards patient-tailored management.

Funder

National Science and Technology Council

Publisher

Frontiers Media SA

Subject

Biochemistry, Genetics and Molecular Biology (miscellaneous),Molecular Biology,Biochemistry

Reference85 articles.

1. Enzyme linked immunosorbent assay;Alhajj,2023

2. Pathogenesis and treatment of psoriasis: Exploiting pathophysiological pathways for precision medicine;Alwan;Clin. Exp. Rheumatol.,2015

3. Serum levels of TNF-alpha, IFN-gamma, IL-6, IL-8, IL-12, IL-17, and IL-18 in patients with active psoriasis and correlation with disease severity;Arican;Mediat. Inflamm.,2005

4. Pathophysiology, clinical presentation, and treatment of psoriasis: A review;Armstrong;Jama,2020

5. Biomarkers-A general review;Aronson;Curr. Protoc. Pharmacol.,2017

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