Author:
Zhang Yan,Khan Suliman,Liu Yang,Zhang Ruiyi,Li Hongmin,Wu Guofeng,Tang Zhouping,Xue Mengzhou,Yong V. Wee
Abstract
Intracerebral hemorrhage (ICH) is a devastating form of stroke with high rates of mortality and morbidity. It induces cell death that is responsible for neurological deficits postinjury. There are no therapies that effectively mitigate cell death to treat ICH. This review aims to summarize our knowledge of ICH-induced cell death with a focus on apoptosis and necrosis. We also discuss the involvement of ICH in recently described modes of cell death including necroptosis, pyroptosis, ferroptosis, autophagy, and parthanatos. We summarize treatment strategies to mitigate brain injury based on particular cell death pathways after ICH.
Funder
National Natural Science Foundation of China
National Key Research and Development Program of China
Innovation Scientists and Technicians Troop Construction Projects of Henan Province
Canadian Institutes of Health Research
Subject
Cellular and Molecular Neuroscience
Cited by
34 articles.
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