Author:
Yang Yu-Shen,He Shi-Ling,Chen Wei-Can,Wang Cong-Mei,Huang Qiao-Mei,Shi Yan-Chuan,Lin Shu,He He-fan
Abstract
Postoperative cognitive dysfunction (POCD), especially in elderly patients, is a serious complication characterized by impairment of cognitive and sensory modalities after surgery. The pathogenesis of POCD mainly includes neuroinflammation, neuronal apoptosis, oxidative stress, accumulation of Aβ, and tau hyperphosphorylation; however, the exact mechanism remains unclear. Non-coding RNA (ncRNA) may play an important role in POCD. Some evidence suggests that microRNA, long ncRNA, and circular RNA can regulate POCD-related processes, making them promising biomarkers in POCD diagnosis, treatment, and prognosis. This article reviews the crosstalk between ncRNAs and POCD, and systematically discusses the role of ncRNAs in the pathogenesis and diagnosis of POCD. Additionally, we explored the possible mechanisms of ncRNA-associated POCD, providing new knowledge for developing ncRNA-based treatments for POCD.
Funder
Natural Science Foundation of Fujian Province
Science and Technology Bureau of Quanzhou
Fujian Provincial Health Technology Project
National Health and Medical Research Council
Subject
Cellular and Molecular Neuroscience
Cited by
3 articles.
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