Abstract
Calorie restriction (CR) is to reduce food intake without malnutrition and is sometimes
adopted intentionally to reduce body weight for improving health. CR has been known to
prolong the lifespan in several animal models such as nematodes, flies, and mice. While it
is not feasible to implement long term CR in humans, the intake of specific food
substances that produce the same effect as CR can result in significant health benefits to
humans. This paper highlights the need for promoting research on such calorie restriction
mimetics (CRMs). This scientific opinion suggests that the promotion of research on
CRMs derived from foods and food resources has the potential to enhance health and
prolong life span. Collaboration between researchers from the fields of food science and
those working on CRMs has the potential to promote good health and enhance human
longevity in the aging society.
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