OTX Genes in Adult Tissues-Reference-Cited by-同舟云学术

OTX Genes in Adult Tissues

Published:2023-11-30 Issue:23 Volume:24 Page:16962
ISSN:1422-0067
Container-title:International Journal of Molecular Sciences
language:en
Short-container-title:IJMS

Author:

Terrinoni Alessandro¹^ORCID,Micheloni Giovanni²^ORCID,Moretti Vittoria²^ORCID,Caporali Sabrina³^ORCID,Bernardini Sergio¹,Minieri Marilena¹^ORCID,Pieri Massimo¹^ORCID,Giaroni Cristina⁴^ORCID,Acquati Francesco²⁵^ORCID,Costantino Lucy⁶,Ferrara Fulvio⁶^ORCID,Valli Roberto²^ORCID,Porta Giovanni²

Affiliation:

1. Department of Experimental Medicine, University of Rome Tor Vergata, Via Montpellier 1, 00133 Rome, Italy

2. Genomic Medicine Research Center, Department of Medicine and Surgery, University of Insubria, Via JH Dunant 5, 21100 Varese, Italy

3. Department of Industrial Engineering, University of Rome Tor Vergata, Via del Politecnico 1, 00133 Rome, Italy

4. Department of Medicina e Innovazione Tecnologica, University of Insubria, Via JH Dunant 5, 21100 Varese, Italy

5. Department of Biotechnology and Life Science, University of Insubria, Via JH Dunant 3, 21100 Varese, Italy

6. Department of Molecular Genetics, Centro Diagnostico Italiano, Via Saint Bon 20, 20147 Milano, Italy

Abstract

OTX homeobox genes have been extensively studied for their role in development, especially in neuroectoderm formation. Recently, their expression has also been reported in adult physiological and pathological tissues, including retina, mammary and pituitary glands, sinonasal mucosa, in several types of cancer, and in response to inflammatory, ischemic, and hypoxic stimuli. Reactivation of OTX genes in adult tissues supports the notion of the evolutionary amplification of functions of genes by varying their temporal expression, with the selection of homeobox genes from the “toolbox” to drive or contribute to different processes at different stages of life. OTX involvement in pathologies points toward these genes as potential diagnostic and/or prognostic markers as well as possible therapeutic targets.

Publisher

MDPI AG

Subject

Inorganic Chemistry,Organic Chemistry,Physical and Theoretical Chemistry,Computer Science Applications,Spectroscopy,Molecular Biology,General Medicine,Catalysis

Link

https://www.mdpi.com/1422-0067/24/23/16962/pdf

Reference163 articles.

1. Chromosome Locations of Human EMX and OTX Genes;Kastury;Genomics,1994

2. The Otx Family;Simeone;Curr. Opin. Genet. Dev.,2002

3. Homeobox Genes in the Developing Central Nervous System;Boncinelli;Ann. Genet.,1993

4. Expression of the Homeobox Genes OTX2 and OTX1 in the Early Developing Human Brain;Larsen;J. Histochem. Cytochem.,2010

5. Forebrain and Midbrain Regions Are Deleted in Otx2−/− Mutants Due to a Defective Anterior Neuroectoderm Specification during Gastrulation;Acampora;Development,1995

Cited by 1 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. OTX1 regulates tumorigenesis and metastasis in glioma;Pathology - Research and Practice;2024-02