Antibacterial Effect and Therapy of Chronic Skin Defects Using the Composite Bioscaffold Polycaprolactone/GelitaSpon/Povidone-Iodine in Domestic Dogs

Author:

Šišková Barbora1,Kožár Martin1ORCID,Staroňová Radka1,Shepa Ivan2,Hajdučková Vanda3,Hudecová Patrícia3,Kaduková Michaela4,Schnitzer Marek5ORCID

Affiliation:

1. Small Animal Clinic, University of Veterinary Medicine and Pharmacy, Komenského 73, 041 81 Košice, Slovakia

2. Institute of Material Research, Slovak Academy of Sciences, 040 01 Košice, Slovakia

3. Department of Microbiology and Immunology, University of Veterinary Medicine and Pharmacy, Komenského 73, 041 81 Košice, Slovakia

4. Department of Parasitology, University of Veterinary Medicine and Pharmacy, Komenského 73, 041 81 Košice, Slovakia

5. Faculty of Mechanical Engineering, Department of Biomedical Engineering and Measurement, Technical University of Košice, Letná 9, 042 00 Košice, Slovakia

Abstract

Chronic wounds and the failure of conventional treatment are relatively common in veterinary medicine. Recently, there has been a growing interest in alternative therapeutic approaches and the utilization of biodegradable materials. Their potential application in wound therapy may offer a novel and more suitable option compared to conventional treatment methods. Biodegradable materials can be classified into two main categories: natural, synthetic, and a combination of both, which have the potential to have synergistically enhanced properties. In this study, four domestic dogs with clinical symptoms of chronic wounds were enrolled. These wounds underwent treatment utilizing a novel biodegradable composite material composed of gelatin sponge combined with two electrospun layers of polycaprolactone (PCL) along with polyvinylpyrrolidone (PVP) fibers containing povidone-iodine complex (PVP-I). The initial phase of the study was dedicated to evaluating the antibacterial properties of iodine against Staphylococcus aureus and Escherichia coli. On average, wound healing in domestic dogs took 22 days from the initial treatment, and iodine concentrations demonstrated a significant antibacterial effect against Escherichia coli and Staphylococcus aureus. Based on the favorable outcomes observed in wound management, we believe that the utilization of a blend of natural and synthetic biodegradable materials holds promise as an effective wound therapy option.

Funder

Slovak Research and Development Agency

Cultural and Educational Grant Agency

Publisher

MDPI AG

Subject

Polymers and Plastics,General Chemistry

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