Lnc-uc.147 Is Associated with Disease Stage of Liver, Gastric, and Renal Cancer-Reference-Cited by-同舟云学术

Lnc-uc.147 Is Associated with Disease Stage of Liver, Gastric, and Renal Cancer

Published:2023-01-31 Issue:2 Volume:13 Page:265
ISSN:2218-273X
Container-title:Biomolecules
language:en
Short-container-title:Biomolecules

Author:

Rodrigues Ana Carolina¹^ORCID,Zambalde Erika Pereira¹²^ORCID,Bellan Daniel de Lima³,Trindade Edvaldo da Silva³^ORCID,Ribeiro Enilze Maria de Souza Fonseca¹^ORCID,Calin George⁴⁵^ORCID,Gradia Daniela Fiori¹^ORCID,Carvalho de Oliveira Jaqueline¹^ORCID

Affiliation:

1. Laboratory of Human Cytogenetics and Oncogenetics, Department of Genetics, Universidade Federal do Paraná, Curitiba 19031, PR, Brazil

2. Multidisciplinary Laboratory of Food and Health, School of Applied Sciences, State University of Campinas, Limeira 13484-350, SP, Brazil

3. Department of Cell Biology, Universidade Federal do Paraná, Curitiba 19031, PR, Brazil

4. Department of Experimental Therapeutics, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA

5. Center for RNA Interference and Non-Coding RNAs, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA

Abstract

Lnc-uc.147, a long non-coding RNA derived from a transcribed ultraconserved region (T-UCR), was previously evidenced in breast cancer. However, the role of this region in other tumor types was not previously investigated. The present study aimed to investigate lnc-uc.147 in different types of cancer, as well as to suggest lnc-uc.147 functional and regulation aspects. From solid tumor datasets analysis of The Cancer Genome Atlas (TCGA), deregulated lnc-uc.147 expression was associated with the histologic grade of hepatocellular carcinoma, and with the tumor stage of clear cell renal and gastric adenocarcinoma. Considering the epidemiologic relevance of liver cancer, silencing lnc-uc.147 reduced the viability and clonogenic capacity of HepG2 cell lines. Additionally, we suggest a relation between the transcription factor TEAD4 and lnc-uc.147 in liver and breast cancer cells.

Funder

MD Anderson Cancer Center, CNPq, CAPES, and PRPPG/UFPR

Publisher

MDPI AG

Subject

Molecular Biology,Biochemistry

Link

https://www.mdpi.com/2218-273X/13/2/265/pdf

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