Affiliation:
1. Human Nutrition Program, The Ohio State University, Columbus, OH 43210, USA
2. Department of Nutritional Sciences, The Pennsylvania State University, University Park, PA 16802, USA
3. Department of Food Science and Technology, The Ohio State University, Columbus, OH 43210, USA
Abstract
Catechins in green tea extract (GTE) (epigallocatechin gallate (EGCG), epigallocatechin (EGC), epicatechin (EC), epicatechin gallate (ECG)) vary in bioactivity. We developed a physiologically relevant mathematical model of catechin metabolism to test the hypothesis that fractional catabolic rates of catechins would be differentially affected by their structural attributes. Pharmacokinetic data of plasma and urine catechin concentrations were used from healthy adults (n = 19) who ingested confections containing 0.5 g GTE (290 mg EGCG, 87 mg EGC, 39 mg EC, 28 mg ECG). A 7-compartmental model of catechin metabolism comprised of the gastrointestinal tract (stomach, small and large intestine), liver, plasma, extravascular tissues, and kidneys was developed using a mean fraction dose of EGCG, ECG, EGC, and EC. Fitting was by iterative least squares regression analysis, and goodness of fit was ascertained by the estimated variability of parameters (FSD < 0.5). The interaction of gallation and B-ring dihydroxylation most greatly extended plasma residence time such that EGC > EC = EGCG > EGC. The interaction between gallation and B-ring dihydroxylation accelerated the transfer from the upper gastrointestinal tract to the small intestine but delayed subsequent transfers from the small intestine through the liver to plasma and from kidneys to urine. Gallation and B-ring dihydroxylation independently delayed the transfer from plasma to extravascular tissues, except the uptake to kidneys, which was slowed by gallation only. This multi-compartment model, to be validated in a future study, suggests that gallation and B-ring dihydroxylation affect catechin catabolism in a tissue-specific manner and thus their potential bioactivity.
Funder
USDA-NIFA
USDA-HATCH
The Ohio State University Ohio Agricultural Research and Development Center
Subject
Food Science,Nutrition and Dietetics
Reference52 articles.
1. Green Tea Consumption and Risk of Cardiovascular and Ischemic Related Diseases: A Meta-Analysis;Pang;Int. J. Cardiol.,2016
2. Tea Consumption and the Risk of Atherosclerotic Cardiovascular Disease and All-Cause Mortality: The China-Par Project;Wang;Eur. J. Prev. Cardiol.,2020
3. Green Tea (Camellia Sinensis) for the Prevention of Cancer;Filippini;Cochrane Database Syst. Rev.,2020
4. Casanova, E., Salvado, J., Crescenti, A., and Gibert-Ramos, A. (2019). Epigallocatechin Gallate Modulates Muscle Homeostasis in Type 2 Diabetes and Obesity by Targeting Energetic and Redox Pathways: A Narrative Review. Int. J. Mol. Sci., 20.
5. The Anti-Obesity Effects of Green Tea in Human Intervention and Basic Molecular Studies;Huang;Eur. J. Clin. Nutr.,2014
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