Polymeric Microneedles: An Emerging Paradigm for Advanced Biomedical Applications
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Published:2023-05-31
Issue:2
Volume:91
Page:27
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ISSN:2218-0532
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Container-title:Scientia Pharmaceutica
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language:en
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Short-container-title:Sci. Pharm.
Author:
Kulkarni Deepak1ORCID, Gadade Dipak2ORCID, Chapaitkar Nutan1ORCID, Shelke Santosh1ORCID, Pekamwar Sanjay3, Aher Rushikesh1ORCID, Ahire Ankita1ORCID, Avhale Manjusha1ORCID, Badgule Rupali1ORCID, Bansode Radhika1ORCID, Bobade Bhujang1ORCID
Affiliation:
1. Department of Pharmaceutics, Srinath College of Pharmacy, Aurangabad, Maharashtra 431136, India 2. Department of Pharmacy, DSEU Dwarka Campus, Delhi Skill and Entrepreneurship University, New Delhi 110077, India 3. School of Pharmacy, SRTM University, Nanded 431606, India
Abstract
Microneedles are gaining popularity as a new paradigm in the area of transdermal drug delivery for biomedical and healthcare applications. Efficient drug delivery with minimal invasion is the prime advantage of microneedles. The concept of the microneedle array provides an extensive surface area for efficient drug delivery. Various types of inorganics (silicon, ceramic, metal, etc.) and polymeric materials are used for the fabrication of microneedles. The polymeric microneedles have various advantages over other microneedles fabricated using inorganic material, such as biocompatibility, biodegradation, and non-toxicity. The wide variety of polymers used in microneedle fabrication can provide a broad scope for drug delivery and other biomedical applications. Multiple metallic and polymeric microneedles can be functionalized by polymer coatings for various biomedical applications. The fabrication of polymeric microneedles is shifting from conventional to advanced 3D and 4D printing technology. The multifaceted biomedical applications of polymeric microneedles include drug delivery, vaccine delivery, biosensing, and diagnostic applications. Here, we provide the overview of the current and advanced information on polymers used for fabrication, the selection criteria for polymers, biomedical applications, and the regulatory perspective of polymer-based and polymer-coated microneedles, along with a patent scenario.
Subject
Pharmaceutical Science
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