Natural Products for the Treatment of Non-Alcoholic Fatty Liver Disease: A Comprehensive Review

Author:

Nucera Saverio1,Bulotta Rosa Maria1,Ruga Stefano1ORCID,Caminiti Rosamaria1,Serra Maria1,Bava Roberto1ORCID,Castagna Fabio1ORCID,Lupia Carmine23,Marrelli Mariangela4ORCID,Conforti Filomena4ORCID,Statti Giancarlo4,Mollace Vincenzo156,Palma Ernesto156ORCID

Affiliation:

1. Department of Health Sciences, University of Catanzaro Magna Græcia, 88100 Catanzaro, Italy

2. Mediterranean Ethnobotanical Conservatory, 88054 Catanzaro, Italy

3. National Ethnobotanical Conservatory, 85040 Potenza, Italy

4. Department of Pharmacy, Health and Nutritional Sciences, University of Calabria, 87036 Cosenza, Italy

5. Department of Health Sciences, Institute of Research for Food Safety & Health (IRC-FISH), University of Catanzaro Magna Græcia, 88100 Catanzaro, Italy

6. Nutramed S.c.a.r.l., Complesso Ninì Barbieri, 88021 Catanzaro, Italy

Abstract

Plants are an untapped natural resource; their secondary metabolites take part in a variety of pharmacological activities, making them an essential ingredient in the synthesis of novel medications and the source of reserve resources in this process. Hepatitis and liver cancer are two conditions that can result from non-alcoholic fatty liver disease (NAFLD). NAFLD is a condition that now affects a significant section of the global population. There is a need for preventative action on predisposing factors. Due to their effectiveness and few side effects, herbal medications are frequently utilized for the prevention and treatment of NAFLD. This review discusses the pathogenetic processes of NAFLD and the evidence brought to support the potential of botanical species and their derivatives in limiting the causes that predispose to the onset of NAFLD.

Publisher

MDPI AG

Subject

Pharmaceutical Science

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