Understanding CNS Effects of Antimicrobial Drugs Using Zebrafish Models-Reference-Cited by-同舟云学术

Understanding CNS Effects of Antimicrobial Drugs Using Zebrafish Models

Published:2023-01-29 Issue:2 Volume:10 Page:96
ISSN:2306-7381
Container-title:Veterinary Sciences
language:en
Short-container-title:Veterinary Sciences

Author:

Kotova Maria M.¹,Galstyan David S.²³⁴,Kolesnikova Tatiana O.¹⁵,de Abreu Murilo S.⁶^ORCID,Amstislavskaya Tamara G.⁷⁸,Strekalova Tatyana⁹¹⁰^ORCID,Petersen Elena V.¹¹,Yenkoyan Konstantin B.⁴¹²^ORCID,Demin Konstantin A.²¹³^ORCID,Kalueff Allan V.¹²³⁴⁵⁷¹³^ORCID

Affiliation:

1. Neuroscience Program, Sirius University of Science and Technology, 354340 Sochi, Russia

2. Institute of Translational Biomedicine, St. Petersburg State University, 199034 St. Petersburg, Russia

3. Laboratory of Preclinical Bioscreening, Granov Russian Research Center of Radiology and Surgical Technologies, Ministry of Healthcare of Russian Federation, 197758 Pesochny, Russia

4. Neuroscience Laboratory, COBRAIN Center, Yerevan State Medical University Named after M. Heratsi, Yerevan 0025, Armenia

5. Institute of Chemical Technology, Ural Federal University, 620002 Yekaterinburg, Russia

6. Bioscience Institute, University of Passo Fundo, Passo Fundo 99052, Brazil

7. Laboratory of Biopsychiatry, Scientific Research Institute of Neurosciences and Medicine, 630117 Novosibirsk, Russia

8. Zelman School of Medicine and Psychology, Novosibirsk State University, 630091 Novosibirsk, Russia

9. Department of Psychiatry and Neuropsychology, University of Maastricht, 6229 ER Maastricht, The Netherlands

10. Research Institute of General Pathology and Pathophysiology, 109544 Moscow, Russia

11. Moscow Institute of Physics and Technology, 141701 Moscow, Russia

12. Biochemistry Department, Yerevan State Medical University Named after M. Heratsi, Yerevan 0025, Armenia

13. Institute of Experimental Medicine, Almazov National Medical Research Centre, Ministry of Healthcare of Russian Federation, 197341 St. Petersburg, Russia

Abstract

Antimicrobial drugs represent a diverse group of widely utilized antibiotic, antifungal, antiparasitic and antiviral agents. Their growing use and clinical importance necessitate our improved understanding of physiological effects of antimicrobial drugs, including their potential effects on the central nervous system (CNS), at molecular, cellular, and behavioral levels. In addition, antimicrobial drugs can alter the composition of gut microbiota, and hence affect the gut–microbiota–brain axis, further modulating brain and behavioral processes. Complementing rodent studies, the zebrafish (Danio rerio) emerges as a powerful model system for screening various antimicrobial drugs, including probing their putative CNS effects. Here, we critically discuss recent evidence on the effects of antimicrobial drugs on brain and behavior in zebrafish, and outline future related lines of research using this aquatic model organism.

Funder

St. Petersburg State University

Sirius University of Science and Technology

Publisher

MDPI AG

Subject

General Veterinary

Link

https://www.mdpi.com/2306-7381/10/2/96/pdf

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