Hepadnavirus Infection in a Cat with Chronic Liver Disease: A Multi-Disciplinary Diagnostic Approach-Reference-Cited by-同舟云学术

Hepadnavirus Infection in a Cat with Chronic Liver Disease: A Multi-Disciplinary Diagnostic Approach

Published:2023-11-24 Issue:12 Volume:10 Page:668
ISSN:2306-7381
Container-title:Veterinary Sciences
language:en
Short-container-title:Veterinary Sciences

Author:

Capozza Paolo¹^ORCID,Pellegrini Francesco¹^ORCID,Camero Michele¹,Diakoudi Georgia¹^ORCID,Omar Ahmed Hassan¹^ORCID,Salvaggiulo Anna¹,Decaro Nicola¹^ORCID,Elia Gabriella¹,Catucci Leonardo²,Di Martino Barbara³^ORCID,Fruci Paola³^ORCID,Tomassini Letizia⁴,Lepri Elvio⁵^ORCID,Martella Vito¹^ORCID,Lanave Gianvito¹^ORCID

Affiliation:

1. Department of Veterinary Medicine, University of Bari, 70010 Bari, Italy

2. ACV Triggiano S.r.l., 70019 Triggiano, Italy

3. Faculty of Veterinary Medicine, University of Teramo, 64100 Teramo, Italy

4. Istituto Zooprofilattico Sperimentale dell’Umbria e delle Marche, 06126 Perugia, Italy

5. Department of Veterinary Medicine, University of Perugia, 06126 Perugia, Italy

Abstract

A 3-year-old female stray, shorthair cat, with clinical signs and serum chemistry markers indicative of hepatic disease, was diagnosed with domestic cat hepadnavirus (DCH) infection. Coupling molecular and serological data, the infection was seemingly contextualized into a chronic phase, since IgM anti-core antibodies, a marker of early-stage Hepatitis B Virus (HBV) infection, were not detected. However, the cat possessed IgG anti-core, a common indicator of chronic HBV infection in human patients and did not show seroconversion to the anti-DCH surface antigen, considered protective during HBV infection and associated with long-term protective immunity. On genome sequencing, the DCH strain showed 98.3% nucleotide identity to strains previously identified in Italy.

Funder

EU funding within the MUR PNRR Extended Partnership initiative on Emerging Infectious Diseases

Publisher

MDPI AG

Subject

General Veterinary

Link

https://www.mdpi.com/2306-7381/10/12/668/pdf

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