Benzene Exposure and MicroRNAs Expression: In Vitro, In Vivo and Human Findings

Author:

Mozzoni PaolaORCID,Poli DianaORCID,Pinelli Silvana,Tagliaferri SaraORCID,Corradi MassimoORCID,Cavallo DeliaORCID,Ursini Cinzia Lucia,Pigini Daniela

Abstract

MicroRNAs (miRNAs) are important regulators of gene expression and define part of the epigenetic signature. Their influence on human health is established and interest in them is progressively increasing. Environmental and occupational risk factors affecting human health include chemical agents. Benzene represents a pollutant of concern due to its ubiquity and because it may alter gene expression by epigenetic mechanisms, including miRNA expression changes. This review summarizes recent findings on miRNAs associated with benzene exposure considering in vivo, in vitro and human findings in order to better understand the molecular mechanisms through which benzene induces toxic effects and to evaluate whether selected miRNAs may be used as biomarkers associated with benzene exposure. Original research has been included and the study selection, data extraction and assessments agreed with PRISMA criteria. Both in vitro studies and human results showed a variation in miRNAs’ expression after exposure to benzene. In vivo surveys also exhibited this trend, but they cannot be regarded as conclusive because of their small number. However, this review confirms the potential role of miRNAs as “early warning” signals in the biological response induced by exposure to benzene. The importance of identifying miRNAs’ expression, which, once validated, might work as sentinel molecules to better understand the extent of the exposure to xenobiotics, is clear. The identification of miRNAs as a molecular signature associated with specific exposure would be advantageous for disease prevention and health promotion in the workplace.

Publisher

MDPI AG

Subject

Health, Toxicology and Mutagenesis,Public Health, Environmental and Occupational Health

Reference73 articles.

1. Sustainable production of benzene from lignin;Meng;Nat. Commun.,2021

2. The toxicity of benzene and its metabolism and molecular pathology in human risk assessment;Anderson;Br. J. Ind. Med.,1991

3. Benzene exposure: An overview of monitoring methods and their findings;Weisel;Chem. Biol. Interact.,2010

4. (2022, November 07). ANNEX XVII TO REACH—Conditions of Restriction (echa.europa.eu). Available online: https://echa.europa.eu/documents/10162/7c8cf4ac-baf9-a05a-2cc7-c9bca4a9d5b7.

5. (2022, November 07). Directive 2008/50/EC of the European Parliament and of the Council of 21 May 2008 on Ambient Air Quality and Cleaner Air for Europe. Available online: http://eur-lex.europa.eu/legal-content/en/ALL/?uri=CELEX:32008L0050.

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3