Passing of Nanocarriers across the Histohematic Barriers: Current Approaches for Tumor Theranostics
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Published:2023-03-23
Issue:7
Volume:13
Page:1140
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ISSN:2079-4991
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Container-title:Nanomaterials
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language:en
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Short-container-title:Nanomaterials
Author:
Gareev Kamil12ORCID, Tagaeva Ruslana13ORCID, Bobkov Danila13ORCID, Yudintceva Natalia13ORCID, Goncharova Daria13, Combs Stephanie E.4, Ten Artem5, Samochernych Konstantin3, Shevtsov Maxim1345ORCID
Affiliation:
1. Institute of Cytology of the Russian Academy of Sciences (RAS), 194064 Saint Petersburg, Russia 2. Department of Micro and Nanoelectronics, Saint Petersburg Electrotechnical University “LETI”, 197022 Saint Petersburg, Russia 3. Personalized Medicine Centre, Almazov National Medical Research Centre, 2 Akkuratova Str., 197341 Saint Petersburg, Russia 4. Department of Radiation Oncology, Technishe Universität München (TUM), Klinikum rechts der Isar, Ismaningerstr. 22, 81675 Munich, Germany 5. Institute of Life Sciences and Biomedicine, Far Eastern Federal University, 690922 Vladivostok, Russia
Abstract
Over the past several decades, nanocarriers have demonstrated diagnostic and therapeutic (i.e., theranostic) potencies in translational oncology, and some agents have been further translated into clinical trials. However, the practical application of nanoparticle-based medicine in living organisms is limited by physiological barriers (blood–tissue barriers), which significantly hampers the transport of nanoparticles from the blood into the tumor tissue. This review focuses on several approaches that facilitate the translocation of nanoparticles across blood–tissue barriers (BTBs) to efficiently accumulate in the tumor. To overcome the challenge of BTBs, several methods have been proposed, including the functionalization of particle surfaces with cell-penetrating peptides (e.g., TAT, SynB1, penetratin, R8, RGD, angiopep-2), which increases the passing of particles across tissue barriers. Another promising strategy could be based either on the application of various chemical agents (e.g., efflux pump inhibitors, disruptors of tight junctions, etc.) or physical methods (e.g., magnetic field, electroporation, photoacoustic cavitation, etc.), which have been shown to further increase the permeability of barriers.
Funder
DFG funding program Open Access Publishing, Ministry of Science and Higher Education of the Russian Federation
Subject
General Materials Science,General Chemical Engineering
Reference246 articles.
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