CAR-T Cell Therapy—An Overview of Targets in Gastric Cancer

Author:

Bębnowska Dominika,Grywalska EwelinaORCID,Niedźwiedzka-Rystwej PaulinaORCID,Sosnowska-Pasiarska Barbara,Smok-Kalwat Jolanta,Pasiarski Marcin,Góźdź Stanisław,Roliński Jacek,Polkowski Wojciech

Abstract

Gastric cancer (GC) is one of the most commonly diagnosed malignancies and, unfortunately, still has a high mortality rate. Recent research points to CAR-T immunotherapy as a promising treatment for this disease. Using genetically engineered T cells designed to target a previously selected antigen, researchers are able to harness the natural anti-tumor activity of T cells. For therapy to be successful, however, it is essential to choose antigens that are present on tumor cells but not on healthy cells. In this review, we present an overview of the most important targets for CAR-T therapy in the context of GC, including their biologic function and therapeutic application. A number of clinical studies point to the following as important markers in GC: human epidermal growth factor receptor 2, carcinoembryonic antigen, mucin 1, epithelial cell adhesion molecule, claudin 18.2, mesothelin, natural-killer receptor group 2 member D, and folate receptor 1. Although these markers have been met with some success, the search for new and improved targets continues. Key among these novel biomarkers are the B7H6 ligand, actin-related protein 2/3 (ARP 2/3), neuropilin-1 (NRP-1), desmocollin 2 (DSC2), anion exchanger 1 (AF1), and cancer-related antigens CA-72-4 and CA-19-9.

Funder

Uniwersytet Medyczny w Lublinie

Narodowe Centrum Nauki

Publisher

MDPI AG

Subject

General Medicine

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