Magnesium-Rich Calcium Phosphate Derived from Tilapia Bone Has Superior Osteogenic Potential

Author:

Cao Xiaxin1,Zhu Jiaqi1,Zhang Changze1,Xian Jiaru1,Li Mengting1ORCID,Nath Varma Swastina2ORCID,Qin Ziyu1,Deng Qiaoyuan3,Zhang Xinyue1,Yang Wei14,Liu Chaozong12ORCID

Affiliation:

1. Hainan Provincial Fine Chemical Engineering Research Center, Hainan University, Haikou 570228, China

2. Institute of Orthopaedic & Musculoskeletal Science, University College London, Royal National Orthopaedic Hospital, London HA7 4LP, UK

3. Key Laboratory of Advanced Material of Tropical Island Resources of Educational Ministry School of Materials Science and Engineering, Hainan University, Haikou 570228, China

4. Hainan Xiangtai Fishery Co., Ltd., South of Yutang Road, Industrial Avenue, Laocheng Development Zone, Chengmai City 571924, China

Abstract

We extracted magnesium-rich calcium phosphate bioceramics from tilapia bone using a gradient thermal treatment approach and investigated their chemical and physicochemical properties. X-ray diffraction showed that tilapia fish bone-derived hydroxyapatite (FHA) was generated through the first stage of thermal processing at 600–800 °C. Using FHA as a precursor, fish bone biphasic calcium phosphate (FBCP) was produced after the second stage of thermal processing at 900–1200 °C. The beta-tricalcium phosphate content in the FBCP increased with an increasing calcination temperature. The fact that the lattice spacing of the FHA and FBCP was smaller than that of commercial hydroxyapatite (CHA) suggests that Mg-substituted calcium phosphate was produced via the gradient thermal treatment. Both the FHA and FBCP contained considerable quantities of magnesium, with the FHA having a higher concentration. In addition, the FHA and FBCP, particularly the FBCP, degraded faster than the CHA. After one day of degradation, both the FHA and FBCP released Mg2+, with cumulative amounts of 4.38 mg/L and 0.58 mg/L, respectively. Furthermore, the FHA and FBCP demonstrated superior bone-like apatite formation; they are non-toxic and exhibit better osteoconductive activity than the CHA. In light of our findings, bioceramics originating from tilapia bone appear to be promising in biomedical applications such as fabricating tissue engineering scaffolds.

Funder

Natural Science Foundation of Hainan Province

MRC-UCL Therapeutic Acceleration Support (TAS) Fund

NIHR UCLH BRC-UCL Therapeutic Acceleration Support (TAS) Fund

Engineering and Physical Sciences Research Council via the DTP CASE Program

Publisher

MDPI AG

Subject

Biomedical Engineering,Biomaterials

Reference65 articles.

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