Preimplantation Genetic Testing for Genetic Diseases: Limits and Review of Current Literature

Author:

Giuliano Roberta1,Maione Anna2,Vallefuoco Angela3,Sorrentino Ugo4ORCID,Zuccarello Daniela4ORCID

Affiliation:

1. Preimplantation Genetic Diagnosis, Department of Women’s and Children’s Health, University of Padova, 35128 Padova, Italy

2. Fertility Unit, Maternal-Child Department, AOU Federico II, 80131 Naples, Italy

3. Department of Clinical Medicine and Surgery, University of Naples Federico II, 80138 Naples, Italy

4. Clinical Genetics and Epidemiology Unit, University Hospital of Padova, Via Giustiniani 3, 35128 Padova, Italy

Abstract

Preimplantation genetic testing (PGT) has emerged as a revolutionary technique in the field of reproductive medicine, allowing for the selection and transfer of healthy embryos, thus reducing the risk of transmitting genetic diseases. However, despite remarkable advancements, the implementation of PGT faces a series of limitations and challenges that require careful consideration. This review aims to foster a comprehensive reflection on the constraints of preimplantation genetic diagnosis, encouraging a broader discussion about its utility and implications. The objective is to inform and guide medical professionals, patients, and society overall in the conscious and responsible adoption of this innovative technology, taking into account its potential benefits and the ethical and practical challenges that it presents.

Funder

European Union

Publisher

MDPI AG

Subject

Genetics (clinical),Genetics

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