Prognostic Role of Neutrophil, Monocyte and Platelet to Lymphocyte Ratios in Advanced Ovarian Cancer According to the Time of Debulking Surgery
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Published:2023-07-13
Issue:14
Volume:24
Page:11420
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ISSN:1422-0067
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Container-title:International Journal of Molecular Sciences
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language:en
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Short-container-title:IJMS
Author:
Plaja Andrea1ORCID, Teruel Iris1, Ochoa-de-Olza Maria1, Cucurull Marc1ORCID, Arroyo Álvaro Javier2, Pardo Beatriz2, Ortiz Irene2, Gil-Martin Marta2, Piulats Josep María2, Pla Helena3ORCID, Fina Claudia3, Carbó Anna3ORCID, Barretina-Ginesta Maria-Pilar3, Martínez-Román Sergio4ORCID, Carballas Elvira4, González Andrea1, Esteve Anna1ORCID, Romeo Margarita1ORCID
Affiliation:
1. Medical Oncology Department, Institut Català d’Oncologia (ICO)-Badalona, Badalona Applied Research Group in Oncology (BARGO), Institut d’Investigació Germans Trias i Pujol (IGTP), 08916 Badalona, Spain 2. Medical Oncology Department, Institut Català d’Oncologia (ICO)-L’Hospitalet, Hospital Duran i Reynals, Institut d’Investigació de Bellvitge (IDIBELL), 08908 Barcelona, Spain 3. Medical Oncology Department, Institut Català d’Oncologia (ICO)-Girona, Girona Biomedical Research Institut d’Investigació Biomèdica de Girona (IDIBGi), 17007 Girona, Spain 4. Obstetrics and Gynecologycal Department, Hospital Germans Trias i Pujol, 08916 Badalona, Spain
Abstract
Despite a multimodal radical treatment, mortality of advanced epithelial ovarian cancer (AEOC) remains high. Host-related factors, such as systemic inflammatory response and its interplay with the immune system, remain underexplored. We hypothesized that the prognostic impact of this response could vary between patients undergoing primary debulking surgery (PDS) and those undergoing interval debulking surgery (IDS). Therefore, we evaluated the outcomes of two surgical groups of newly diagnosed AEOC patients according to the neutrophil, monocyte and platelet to lymphocyte ratios (NLR, MLR, PLR), taking median ratio values as cutoffs. In the PDS group (n = 61), low NLR and PLR subgroups showed significantly better overall survival (not reached (NR) vs. 72.7 months, 95% confidence interval [CI]: 40.9–95.2, p = 0.019; and NR vs. 56.1 months, 95% CI: 40.9–95.2, p = 0.004, respectively) than those with high values. Similar results were observed in progression free survival. NLR and PLR-high values resulted in negative prognostic factors, adjusting for residual disease, BRCA1/2 status and stage (HR 2.48, 95% CI: 1.03–5.99, p = 0.043, and HR 2.91, 95% CI: 1.11–7.64, p = 0.03, respectively). In the IDS group (n = 85), ratios were not significant prognostic factors. We conclude that NLR and PLR may have prognostic value in the PDS setting, but none in IDS, suggesting that time of surgery can modulate the prognostic impact of baseline complete blood count (CBC).
Subject
Inorganic Chemistry,Organic Chemistry,Physical and Theoretical Chemistry,Computer Science Applications,Spectroscopy,Molecular Biology,General Medicine,Catalysis
Cited by
1 articles.
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