Benefits and Meaning of Lipids Profile in Relation to Oxidative Balance and Brain Morphology in Schizophrenia

Author:

Śmierciak Natalia1,Krzyściak Wirginia2ORCID,Szwajca Marta1ORCID,Karcz Paulina3,Bryll Amira4,Popiela Tadeusz J.4ORCID,Donicz Paulina1,Turek Aleksander5,Aleksandrovych Veronika6ORCID,Pilecki Maciej1

Affiliation:

1. Department of Child and Adolescent Psychiatry, Faculty of Medicine, Jagiellonian University Medical College, 31-501 Krakow, Poland

2. Department of Medical Diagnostics, Jagiellonian University Medical College, 30-688 Krakow, Poland

3. Department of Electroradiology, Jagiellonian University Medical College, 31-126 Krakow, Poland

4. Department of Radiology, Jagiellonian University Medical College, 31-501 Krakow, Poland

5. Doctoral School of Medical and Health Sciences, Jagiellonian University Medical College, 31-530 Krakow, Poland

6. Department of Pathophysiology, Jagiellonian University Medical College, 31-121 Krakow, Poland

Abstract

Schizophrenia is characterized by complex metabolic dysregulations and their consequences. Until now, numerous theories have explained its pathogenesis, using a spectrum of available technologies. We focused our interest on lipid profile—periphery high-density cholesterol level and lipoproteins in the human brain and compared magnetic resonance imaging (MRI) scans of patients with schizophrenia and the healthy group. Detailed analysis of biochemical parameters was performed using magnetic resonance spectroscopy. Our study aimed to reveal correlations between periphery high-density lipoproteins levels and lipoproteins in the brain, depicted in MRI scans, and parameters of peripheral oxidative stress expressed as paraoxonase. Patients with schizophrenia have decreased levels of high-density lipoproteins, low paraoxonase activity, and slightly raised sodium in the blood. Positive significant correlations between serum high-density cholesterol and anterior cingulate cortex, unique brain area for schizophrenia pathophysiology, MR spectroscopy signals, and diffusion have been revealed. To our knowledge, this is the first study to describe the effect of an anterior cingulate disorder on high-density cholesterol levels on the development of schizophrenia.

Publisher

MDPI AG

Subject

Inorganic Chemistry,Organic Chemistry,Physical and Theoretical Chemistry,Computer Science Applications,Spectroscopy,Molecular Biology,General Medicine,Catalysis

Reference67 articles.

1. Schizophrenia;Freedman;N. Engl. J. Med.,2003

2. Oxidative stress biomarkers in treatment-responsive and treatment-resistant schizophrenia patients;Buosi;Trends Psychiatry Psychother.,2021

3. Changes in serum interleukin-2, -6, and -8 levels before and during treatment with risperidone and haloperidol: Relationship to outcome in schizophrenia;Zhang;J. Clin. Psychiatry,2004

4. Interleukin 10 promotes macrophage uptake of HDL and LDL by stimulating fluid-phase endocytosis;Lucero;Biochim. Biophys. Acta Mol. Cell Biol. Lipids,2020

5. Oxidative Stress-Related Mechanisms in Schizophrenia Pathogenesis and New Treatment Perspectives;Ermakov;Oxidative Med. Cell. Longev.,2021

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